Brighten and even skin tone with an exclusive combination of active ingredients that corrects and regulates all types of pigmentation.

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What is Cosmelan?

Cosmelan is an in-clinic depigmentation treatment that acts as an enzyme to reduce and inhibit the production of melanin. Its dual-action approach to treating dermal pigmentation both corrects blemishes and regulates melanin production.

Corrective Action

By stimulating the renewal of the epidermis, blemishes are lifted, skin is brightened and tone is evened. This corrective process reduces the amount of melanin synthesised and unwanted pigmentation fades away.

Regulating Action

By inhibiting the activation of tyrosinase inside the melanosome (where pigment is formed), oxidative stress is reduced and melanin synthesis becomes inhibited. Copper chelators (Cu2+) further regulate tyrosinase function and effectively block the transfer of melanin to the skin surface, preventing new pigmentation.

Is There Downtime?

It may be necessary to take time off work and not plan any social events in the few days following your treatment. Your skin will begin to peel and flake off and may feel very tight and dry. Despite the feeling of discomfort, tightness and peeling skin, it is extremely important not to pick or peel at your skin as this may damage the healthy new skin underneath or cause infection.

Strict adherence to the home maintenance program at this time is essential and your Skin Specialist can recommend additional treatments and skincare products to assist with any discomfort you may experience.


The results of the treatment become evident by about days 10-14 with visibly clearer and brighter skin. Ongoing improvement in the skin can be seen over the next few months.

The Cosmelan Complete Treatment Program

1. Intense De-Pigmentation

Following your in-clinic application of the cosmelan 1 mask, allow it to act for 8-12 hours according to the recommendations of your Specialist.

To remove the mask at home, rinse carefully with plenty of lukewarm water, multiple times if necessary, avoiding direct contact with the eyes. In case of redness, tightness or a sensation of dryness, we recommend applying a layer of hydra-vital factor k, allowing it to act for 10-15 minutes.

2. Continuous De-Pigmentation

Month 1 (At home)

2-4 Days after the Cosmelan 1 mask, continue the daily de-pigmentation routine with Cosmelan 2 to supplement the corrective action and to regulate the production of melanin.

Apply Cosmelan 2 three times a day (morning, midday and night), followed by hydra-vital factor k and moisturising sun protection after daytime applications.

3. Control of Hyperpigmentation

Months 2 and 3 (At home)

At this point, it is important to treat the root cause of the pigmentation by regulating the production of melanin through constant regulation of the melanocyte. This controls both intra- and inter-cellular melanin production and prevents re-pigmentation.

Apply Cosmelan 2 morning and night, followed by hydra-vital factor k, and moisturising sun protection during the day. In case of sun exposure, re-apply SPF protection at midday.

4. Controlling Reappearance

Months 4 to 6 (At home)

The tendency to develop pigmentation represents an ongoing risk. During the control phase, the treatment prevents the reappearance of the treated spots and the formation of new ones, for a longer-lasting result.

Once the Cosmelan system is complete, we strongly recommend continuous use of sun protection as a permanent routine.

Apply cosmelan 2 at night, followed by hydra-vital factor k. During the day, apply moisturising sun protection and reapply in cases of direct sun exposure.


Cosmelan $1,499
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